The Nachtrieb/Kelly Ranch is associated with the history of ranching in Chaffee County, serving as a cattle and hay ranch from the late 1870s to the present.

The 1882 Kelley-McDonald House, substantially completed by 1914, is a well-preserved two-story example of a large frame Queen Anne-style dwelling and upper class family residence in Buena Vista. 

The Jacobs Building is significant at the local level in the area of Commerce from 1888 to 1916 and 1923 to 1954, for its long association with the late 19th century through the mid-twentieth century commercial development of the town of Buena Vista.

The Capitol Annex benefited from two Depression era Federal programs - the Public Works Administration and the Works Progress Administration.  The former program provided part of the funding for this two building complex.

The Colorado National Bank is listed on the National Register for its local significance between 1915 and 1964 in the area of Commerce and Community Planning and Development for its embodiment of the Colorado National Bank’s leadership role in the renaissance of downtown Denver during the post-World War II years. 

The 1883 Rowhouse is one of the most intact examples of its type dating from the late 19th century.

The City and County of Denver established the George W. Clayton Trust and College in 1911 through a bequest by George W.Clayton.  Clayton sought to provide for the guardianship and education of boys whose fathers had died and whose mothers were unable to care for them.  He wanted to provide a cost-free standard of care and education significantly beyond that typical of the time.

Denver architect Frank E. Kidder designed the Gothic Revival style church which opened in 1891. 

The 1903 Cheesman Park Duplex is an important example of a combination of design elements - Mission Revival and Arts & Crafts.  The brick building exhibits excellence in craftsmanship and detailing credited to builder William Thompson.  

Walter S. Cheesman, an early and long-time Denver promoter and developer, began work on the house in 1904.  He died before its completion in 1908.